Overview
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a mitochondria-derived peptide encoded within the mitochondrial genome rather than the nuclear genome — a property that distinguishes it from all other known peptides. This unique origin has made MOTS-C a significant focus of research into mitochondrial signalling, cellular energy regulation, and metabolic homeostasis.
Nova Biolabs supplies MOTS-C in a higher-concentration 40mg vial from Indonesia domestic stock, HPLC-verified at >98% purity — suited to research protocols requiring larger or repeated reconstituted volumes. A 10mg vial is also available for smaller-scale use.
Key Research Areas
Mitochondrial Signalling Research
As a mitochondria-encoded peptide, MOTS-C is studied for its role in retrograde mitochondrial-nuclear signalling and its effects on nuclear gene expression related to energy metabolism.
AMPK Pathway Activation
MOTS-C has been investigated for its ability to activate AMP-activated protein kinase (AMPK), a key cellular energy sensor, in skeletal muscle and liver cell models.
Metabolic Homeostasis Research
Studied in cellular models for its effects on glucose metabolism, insulin signalling, and metabolic flexibility under nutrient-restricted conditions.
Ageing and Longevity Research
Given its mitochondrial origin and role in energy regulation, MOTS-C is of interest in longevity research and age-related metabolic decline studies.
Product Specifications
| Format | Lyophilised powder |
| Quantity | 40mg per vial |
| Purity | >98% (HPLC verified) |
| Storage | Refrigerate at 2–8°C. Stable 24 months lyophilised. |
| Origin | Indonesia domestic stock |
| Research use | In vitro / laboratory use only |